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What Causes Autism?

In short, nobody knows.  In fact, chances are, autism may be caused by a number of factors, or by some combination of factors.  What is known for sure is that parenting styles and discipline have no impact on a child's development of autism.  In the last 5 years money has been poured into autism research.  Hopefully, the near future will bring more definitive answers.

Risk Factors for Autism...

While the cause of autism has not been identified, a number of risk factors for autism have.  They are as follows:

  • Being Male - Males have an almost four-fold risk of autism, compared to females.  Based on those numbers the current risk of a boy developing autism may be greater than 1 in 100.
  • Family History  (Genetic Risk Factors) -  Having a Sibling or other Family member with an Autism Spectrum Disorder increases a child's risk of developing autism substantially.
  • Father Over 40 - Having a Father who was over 40 at the time of the child's birth increases that child's risk of autism.  According to one study the risk may be increased by almost a factor of 6.  Interestingly enough, the mothers' age does not seem to be a risk factor for ASDs.
  • Prematurity - A recent study suggests that being a preemie may put a child at an increased risk of Autism. It was published in the April 2008 Journal of Pediatrics and included 91 children who were born 10 or more weeks prematurely and weighing 4 lbs or less.  23 of those children (or 25%) when screened with the MCHAT questionnaire, showed some signs of autism.  It is unlikely that all those children would ultimately be diagnosed with autism, however the very high screening rates suggest some increased risk.
  • Other Disorders - Having other disorders such as Tourettes, Epilepsy, Fragile X or tuberous sclerosis, (a disorder that causes tumors on the brain) all increase the risk of autism.  These are sometimes referred to as comorbid conditions.

 

What about Vaccines?

It has been suggested by some that vaccines may be responsible for the increase in the rates of autism.  This debate stirs deep emotions and strong-conflict among parents and scientists.  From the perspective of main stream science, a connection between vaccines and the increasing rates of autism is not supported by evidence.  In fact, the CDC, the American Academy of Pediatrics and the FDA all strongly disavow any link between vaccines and autism.  Their position is well supported by a large body of scientific evidence.

An equally large number of parents are convinced that their child became autistic because of vaccinations. Scientists argue that this is a result of the timing of vaccines and of the similar timing of many of the manifestations of autism.  Most scientists suggests that because these two events often occur during the same time period, parents assume a cause and effect relationship that does not exist...  Likening this assumption to suggesting that the sun rises because the rooster crows.

In any event, the suggested link between vaccinations and autism has been suggested to be the result of either of two different mechanisms.  The first mechanism suggested was the presence of the mercury containing preservative, thimerosal in many childhood vaccines (prior to 2001). Mercury is a known neurotoxin, and thus thimerosal became suspect early on in the growing autism epidemic.  Since 2001 however, thimerosal was no longer included in the manufacture of childhood vaccines (with the exception of the flu vaccine). By 2003, most remaining vaccines that had included thimerosal had expired (again, except the flu vaccine and tetanus).  If thimerosal had been the cause of autism, the numbers of children diagnosed with autism would have been expected to drop as exposure to thimerosal dropped.  That has not been the case.  Despite a decrease in exposure to thimerosal, autism rates have continued to climb.  Additionally, a number of well designed studies have shown no link between thimerosal and autism. 

The second mechanism by which vaccines have been suggested to cause autism is the "immune system overload theory". Essentially, proponents of this theory have suggested that a young child's immune system becomes overwhelmed due to the large number of vaccines now given in the early years.  The MMR vaccine particularly has been pointed to by the proponents of this theory, and was initially identified as a possible cause of autism by Andrew Wakefield.  Andrew Wakefield, a physician in the UK, was roundly criticized for his conclusions by the rest of the scientific community.  It turned out that his motives may well have been tainted by money, and that the results he claimed were not replicable by others in the scientific community.  Subsequently, large epidemiological studies have found NO link between autism and MMR.  Concerns have persisted in the public realm despite evidence to the contrary. Proponents of the autism overload theory have claimed that some of these studies might be flawed, but with over a dozen epidemiological studies in different countries using different techniques and reaching the same conclusion..... most scientists agree there is no link.  It seems reasonable to assume that the epidemiological studies rule out the MMR as the sole cause of the rise in autism rates.  This of course does not rule out the possibility that there may be very small numbers of children who are genetically predisposed to being susceptible to harm from vaccinations due to genetic predispositions.

The web contains lots of information about Autism, it's risk factors & hypothesized causes.  Some sources are very credible, and many others are sheer quackery....  Here are some interesting links from very credible and well respected sources you may want to explore:

 

National Media Articles and Shows

Concerning Vaccines & Autism

 

Talk of the Nation (an NPR Show) discusses Vaccines & Autism. 

CNN Video & Article on the Link Between Autism & Vaccines

Businessweek Article on Thimerosal & Autism in California

 

Information Provided by the CDC and

NIH regarding Vaccines and Autism

CDCs Informational Page on Autism & Vaccines

CDCs Summary Sheet of Studies looking for Autism Vaccine Link

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OnSpectrum does not provide medical advice, diagnosis or treatment. Consult your physician if you suspect your child has Autism.
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